Narimatsu/Nakamura Research Lab


Narimatsu/Nakamura Research Lab

Narimatsu・Nakamura Research Team

Our team offers classes on epidemiology at the Graduate School of Health Innovation, including Research on Epidemiology and Seminar on Epidemiology! Join us in our mission to advance the field of epidemiology! Our research activities are closely related to these classes, intending to promote innovative epidemiological research.

In particular, we are committed to working with our students to meet the challenges of integrating science and technology, industrial policy, and health care beyond the traditional boundaries of epidemiology and prevention.

Dr. Narimatsu is also the Director of the Cancer Prevention and Control Division at the Kanagawa Cancer Center Research Institute (Dr. Nakamura is a visiting researcher) and the Chief of the Department of Genetic Medicine at the Kanagawa Cancer Center (concurrently serving in a cross-appointment system). The Cancer Prevention and Control Division has been responsible for the Regional Cancer Registry of the Kanagawa Prefecture for over 30 years. In addition, since 2016, we have been conducting the Kanagawa Prospective “ME-BYO” Cohort Study, which serves as the Kanagawa site of the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study), which is a genomic cohort study.

We also actively engage in collaborative research not only with Kanagawa Prefecture but also with Keio University, Tokai University, Yokohama National University, Yokohama City University, Tokyo Medical and Dental University, and many other academic institutions, as well as many private companies.

In close collaboration with these institutions, we advance our research activities by leveraging our research assets in epidemiology and public health as an intellectual foundation.

Research Themes

Kanagawa Prospective "ME-BYO" Cohort Study

The Kanagawa Prospective "ME-BYO" Cohort Study (ME-BYO Cohort) is a genomic cohort study to clarify the interaction between people's constitution (genomic factors) and their lifestyle habits to clarify the evidence for the prevention of non-communicable diseases such as cancer. The evidence provided by the ME-BYO cohort will also contribute to the "ME-BYO" improvement that Kanagawa Prefecture has set. The ME-BYO cohort is also expected to develop nationally by participating in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study) as a collaborative research project. Since the opening of the Graduate School of Health Innovation, we have also been conducting joint research with the Tohoku Medical Megabank Organization, and our research is making steady progress.

There is one thing we tell our study participants honestly. It will take decades to see the most significant results we hope to achieve from this research. For this reason, we cannot promise that we will be able to return results that will be of any immediate benefit to current participants. On the other hand, we have received comments from participants that they hope this research will help the younger generation, including their children and grandchildren, live healthier and wealthier lives, which would be a great gift.

The ME-BYO cohort is a research project to plant the seeds of health in the "future" and nurture them with our collaborators.


KISTEC has uploaded a YouTube video featuring Dr. Fukuda, a leading researcher and collaborator in the field of microbiome research, and the Director of the ME-BYO Industry Division of Kanagawa Prefecture. The interview discusses the possibilities and approaches of 'ME-BYO science', which aims to create new value and is closely related to the healthy ageing.

ME-BYO & ME-RISE Project

The ME-BYO & ME-RISE project is one of the innovative challenges that our research team is attempting. We are challenging advanced approaches with the keyword "Future Map to ME-BYO (the Japanese translation of this phrase sounds like ME-BYO and ME-RISE)".

Specifically, this project will utilize the assets of cohort studies in a new way to verify how the innovative seeds in health care can be implemented by the public and policymakers as soon as possible. A key focus of this project is the approach to promoting behavior change among participants. We aim to formulate evidence in preventive medicine (especially primary prevention) and integrate it into policy by conducting multifaceted effectiveness verification and focusing on "exit = policy making" at the time of research design.
Thanks to the tremendous support of local governments and health care providers, we are steadily implementing scientific and technological innovations in local communities in close collaboration with them, using epidemiological methods, our specialty, to measure indicators and accurately verify effects.

Notices & Activity Reports

For other details, please refer to the aforementioned the ME-BYO Cohort website!

We are also working on activities related to community health promotion at a specified nonprofit corporation centered in Takahata-machi, Yamagata Prefecture.

For more information, please visit the following link!

The event we hosted on May 31, 2023 was featured.

Major Achievements

2023.4 - 2024.3

  • Konnai K, Fujiwara H, Kitagawa M, Wakabayashi R, Yumori A, Notomi T, Onose R, Kato H, Narimatsu H. Impact of lower co-payments on risk-reducing salpingo-oophorectomy and BRCA testing in Japan. Arch Public Health. 2023 Feb 27;81(1):32.
  • Terao H, Nagasaka H, Yamamoto S, Suzuki A, Usui K, Nakaigawa N, Kishida T, Watanabe K, Nakamura S, Narimatsu H. Screening for prostate cancer in a city in Japan: age-specific prostate-specific antigen cutoff thresholds. Cancer Causes Control. 2024 Apr;35(4):671-677.
  • Washimi K, Kasajima R, Shimizu E, Sato S, Okubo Y, Yoshioka E, Narimatsu H, Hiruma T, Katayama K, Yamaguchi R, Yamaguchi K, Furukawa Y, Miyano S, Imoto S, Yokose T, Miyagi Y. Histological markers, sickle-shaped blood vessels, myxoid area, and infiltrating growth pattern help stratify the prognosis of patients with myxofibrosarcoma/undifferentiated sarcoma. Sci Rep. 2023 Apr 25;13(1):6744.
  • Nakamura S, Watanabe R, Saito Y, Watanabe K, Chung UI, Narimatsu H. The ME-BYO index: A development and validation project of a novel comprehensive health index. Front Public Health. 2023 May 5;11:1142281.
  • Nakamura S, Kanda S, Endo H, Yamada E, Kido M, Sato S, Ogawa I, Inoue R, Togashi M, Izumiya K, Narimatsu H. Effectiveness of a targeted primary preventive intervention in a high-risk group identified using an efficiency score from data envelopment analysis: a randomised controlled trial of local residents in Japan. BMJ Open. 2023 May 16;13(5):e070187.
  • Isaka T, Nagashima T, Adachi H, Narimatsu H, Murakami K, Shigefuku S, Kikunishi N, Shigeta N, Watabe K, Kudo Y, Miyata Y, Okada M, Ikeda N, Ito H. Wedge resection vs. segmentectomy for lung cancer measuring ≤ 2 cm with consolidation tumor ratio > 0.25. Front Oncol. 2023 Aug 28;13:1253414.
  • Saito Y, Nakamura S, Watanabe K, Ikegami H, Shinmura N, Sato S, Miyagi Y, Narimatsu H. Age group differences in psychological distress and leisure-time exercise/socioeconomic status during the COVID-19 pandemic: a cross-sectional analysis during 2020 to 2021 of a cohort study in Japan. Front Public Health. 2023 Oct 25;11:1233942.
  • Watanabe N, Kozaki A, Inoue K, Narimatsu H, Shinohara M, LoPresti MG. Prevalence, Incidence, and Clinical Characteristics of Thyroid Eye Disease in Japan. J Endocr Soc. 2023 Nov 27;8(1):bvad148.
  • Chiang CC, Fang X, Horvath Z, Cadiou F, Urani A, Poh W, Narimatsu H, Cheng Y, Dodick DW. Simultaneous Comparisons of 25 Acute Migraine Medications Based on 10 Million Users' Self-Reported Records From a Smartphone Application. Neurology. 2023 Dec 12;101(24):e2560-e2570.
  • Isaka T, Ito H, Yokose T, Saito H, Narimatsu H, Adachi H, Miura J, Murakami K, Kikunishi N, Shigeta N, Rino Y. Long-term changes in psoas muscle mass after lobectomy and segmentectomy for early-stage lung cancer. J Cachexia Sarcopenia Muscle. 2023 Dec;14(6):2540-2549.
  • Narimatsu H, Feng L. Editorial: Reviews in behavioral and lifestyle interventions for healthy aging: 2022. Front Public Health. 2024 Feb 5;12:1354881.
  • 齋藤義信, 小熊祐子, 中村 翔, 成松宏人, 中嶋綾子, 池崎裕昭, 田中恵太郎, 原 めぐみ, 玉田雄大, 永吉真子, 田村高志, 菱田朝陽, 尾瀬 功, 谷山祐香里, 三上春夫, 永瀬浩喜, 嶽﨑俊郎, 指宿りえ, 鈴木貞夫, 大谷隆浩, 小山晃英, 渡邉 功, 栗木清典, 喜多義邦, 高嶋直敬, 有澤孝吉, 釜野桜子, 竹内研時, 若井建志.J-MICC研究グループ,質問紙で調査した成人の身体活動:日本多施設共同コーホート研究(J-MICC Study).運動疫学研究. 2023, 1347-5827.
  • 中村 翔, 小笠原 悠, 成松 宏人. 包絡分析法の予防医学への応用の挑戦. オペレーションズ・リサーチ. 2023;68(6):294-8.

2022.4 - 2023.3

  • Haneda E, Sato A, Suganuma N, Sebata Y, Okamoto S, Toda S, Kohagura K, Matsubara Y, Sugawara Y, Yamanaka T, Yamashita T, Shimizu S, Narimatsu H. Efficacy of Clinical Guidelines in Identifying All Japanese Patients with Hereditary Breast and Ovarian Cancer. Int J Environ Res Public Health. 2022;19(10). Epub 20220519.
  • Kishi H, Watanabe K, Nakamura S, Taguchi H, Narimatsu H. Impact of nurses' roles and burden on burnout during the COVID-19 pandemic: multicenter cross-sectional survey. J Nurs Manag. 2022. Epub 20220428.
  • Miyaji A, Watanabe K, Takano Y, Nakasho K, Nakamura S, Wang Y, Narimatsu H. A Privacy-Preserving Distributed Medical Data Integration Security System for Accuracy Assessment of Cancer Screening: Development Study of Novel Data Integration System. JMIR Med Inform. 2022;10(12):e38922. Epub 20221230.
  • Hayauchi G, Ariyoshi R, Saito Y, Oguma Y, Nakamura S, Nakamura F. A Review on the Current Situation and Future Perspectives of the Studie on the Relationship between Transportation and Health in Japan. Journal of JSCE D3. 2022;77(5):I_583-I_593.
  • Saito Y, Nakamura S, Tanaka A, Watanabe R, Narimatsu H, Chung U-i. Evaluation of the validity and reliability of the 10-meter walk test using a smartphone application among Japanese older adults. Frontiers in Sports and Active Living. 2022;4:904924. Epub 20221004.
  • Saito Y, Nakamura S, Tanaka A, Watanabe R, Narimatsu H, Chung UI. Checking the validity and reliability of the Japanese version of the Mini-Cog using a smartphone application. BMC Res Notes. 2022;15(1):222. Epub 20220625.
  • Sawaguchi E, Nakamura S, Watanabe K, Tsuno K, Ikegami H, Shinmura N, Saito Y, Narimatsu H. COVID-19-related stigma and its relationship with mental wellbeing: A cross-sectional analysis of a cohort study in Japan. Front Public Health. 2022;10:1010720. Epub 20220929.
  • Takahashi K, Nakamura S, Watanabe K, Sakaguchi M, Narimatsu H. Availability of Financial and Medical Resources for Screening Providers and Its Impact on Cancer Screening Uptake and Intervention Programs. Int J Environ Res Public Health. 2022;19(18). Epub 20220912.
  • Takumoto Y, Sasahara Y, T Murata, Narimatsu H, Akazawa M. Manabu A. Health state utility values for metastatic pancreatic cancer using a composite time trade-off based on the vignette-based approach in Japan. Health Econ Rev. 2022;12(1):63. Epub 20221224.
  • Iwagami M, Goto A, Katagiri R, Sutoh Y, Koyanagi YN, Nakatochi M, Nakano S, Hanyuda A, Narita A, Shimizu A, Tanno K, Hozawa A, Kinoshita K, Oze I, Ito H, Yamaji T, Sawada N, Nakamura Y, Nakamura S, Kuriki K, Suzuki S, Hishida A, Kasugai Y, Imoto I, Suzuki M, Momozawa Y, Takeuchi K, Yamamoto M, Sasaki M, Matsuo K, Tsugane S, Wakai K, Iwasaki M. Blood Lipids and the Risk of Colorectal Cancer: Mendelian Randomization Analyses in the Japanese Consortium of Genetic Epidemiology Studies. Cancer Prev Res (Phila). 2022 Dec 1;15(12):827-836.
  • Nakamura S, Fang X, Saito Y, Narimatsu H, Ota A, Ikezaki H, Shimanoe C, Tanaka K, Kubo Y, Tsukamoto M, Tamura T, Hishida A, Oze I, Koyanagi Y.N, Nakamura Y, Kusakabe M, Takezaki T, Nishimoto D, Suzuki S, Otani T, Kuriyama N, Matsui D, Kuriki K, Kadota A, Nakamura Y, Arisawa K, Katsuura-Kamano S, Nakatochi M, Momozawa Y, Kubo M, Takeuchi K, Wakai K. Effects of gene–lifestyle interactions on obesity based on a multi-locus risk score: A cross-sectional analysis. 2023 Feb 8;18(2): e0279169.
  • Katagiri R, Goto A, Nakano S, Nakatochi M, Koyanagi YN, Iwagami M, Hanyuda A, Yamaji T, Sawada N, Nakamura Y, Nakamura S, Kuriki K, Suzuki S, Imoto I, Momozawa Y, Oze I, Ito H, Tsugane S, Wakai K, Matsuo K, Iwasaki M. Association of 25-hydroxyvitamin D with risk of overall and colorectal cancer among Japanese using a Mendelian randomization approach. Sci Rep. 2023 Feb 10;13(1):2384.
  • Narimatsu H, Yaguchi YT. The Role of Diet and Nutrition in Cancer: Prevention, Treatment, and Survival. Nutrients. 2022 Aug 14;14(16):3329
  • Takumoto Y, Sasahara Y, Narimatsu H, Akazawa M. Comparative Outcomes of First-Line Chemotherapy for Metastatic Pancreatic Cancer Among the Regimens Used in Japan: A Systematic Review and Network Meta-analysis. JAMA Netw Open. 2022 Jan 4;5(1):e2145515.

2021.4 - 2022.3

  • Okamura Y, Sugiura T, Ito T, Yamamoto Y, Ashida R, Ohgi K, Sasaki K, Narimatsu H, Uesaka K. The prognostic roles of the prognostic nutritional index in patients with intraductal papillary mucinous neoplasm. Sci Rep. 2021 Jan 12;11(1):568.
  • Kanouchi K, Narimatsu H, Shirata T, Morikane K. Diagnostic analysis of lupus anticoagulant using clot waveform analysis in activated partial thromboplastin time prolonged cases: A retrospective analysis. Health Sci Rep. 2021 Mar 12;4(2):e258.
  • Okamura Y, Boku N, Ghaneh P, Greenhalf W, Yasukawa S, Narimatsu H, Fukutomi A, Konishi M, Morinaga S, Toyama H, Maeda A, Shimizu Y, Nakamori S, Sata N, Yamakita K, Takahashi A, Takayama W, Yamaguchi R, Tomikawa M, Yanagisawa A, Neoptolemos JP, Uesaka K. Concordance of human equilibrative nucleoside transporter-1 expressions between murine (10D7G2) and rabbit (SP120) antibodies and association with clinical outcomes of adjuvant chemotherapy for pancreatic cancer: A collaborative study from the JASPAC 01 trial. Cancer Rep (Hoboken). 2022 May;5(5):e1507.
  • Enomoto N, Nakamura S, Kanda S, Endo H, Yamada E, Kobayashi S, Kido M, Inoue R, Shimakura J, Narimatsu H. Efficacy of Additional Intervention to the Specific Health Guidance in Japan: The Takahata GENKI Project. Risk Manag Healthc Policy. 2021 Sep 21;14:3935-3943.
  • de Luise C, Sugiyama N, Morishima T, Higuchi T, Katayama K, Nakamura S, Chen H, Nonnenmacher E, Hase R, Jinno S, Kinjo M, Suzuki D, Tanaka Y, Setoguchi S. Validity of claims-based algorithms for selected cancers in Japan: Results from the VALIDATE-J study. Pharmacoepidemiol Drug Saf. 2021 Sep;30(9):1153-1161.
  • Suganuma N, Kawachi K, Yamashita T, Yamanaka T, Sugawara Y, Matsubara Y, Yamazaki H, Kohagura K, Toda S, Okamoto S, Yoshida T, Rino Y, Masuda M, Narimatsu H, Fujita H, Yoshioka E, Yokose T, Furuta K, Miyagi Y. Quality Control of Breast Cancer Surgery Samples: Introducing Time Stamp Checking. Biopreserv Biobank. 2021 Oct;19(5):369-375.
  • Kobayashi S, Koizume S, Takahashi T, Ueno M, Oishi R, Nagashima S, Sano Y, Fukushima T, Tezuka S, Morimoto M, Nakamura S, Narimatsu H, Ruf W, Miyagi Y. Tissue factor and its procoagulant activity on cancer-associated thromboembolism in pancreatic cancer. Cancer Sci. 2021 Nov;112(11):4679-4691.
  • Murano C, Suzuki S, Nakamura S, Takeda H, Fukui T, Yoshioka T. Vimentin-positive and Alpha-fetoprotein-elevated Nuclear Protein of the Testis Midline Carcinoma: A Case Report and Review of the Literature. Intern Med. 2021 Nov 15;60(22):3645-3649.
  • Suzuki H, Narimatsu H, Nakane M, Sadahiro M, Kawamae K. Perioperative presepsin as a potential early predictor for postoperative infectious complications in cardiac surgery. Anaesthesiol Intensive Ther. 2021;53(3):215-222.
  • Takeuchi K, Naito M, Kawai S, Tsukamoto M, Kadomatsu Y, Kubo Y, Okada R, Nagayoshi M, Tamura T, Hishida A, Nakatochi M, Sasakabe T, Hashimoto S, Eguchi H, Momozawa Y, Ikezaki H, Murata M, Furusyo N, Tanaka K, Hara M, Nishida Y, Matsuo K, Ito H, Oze I, Mikami H, Nakamura Y, Kusakabe M, Takezaki T, Ibusuki R, Shimoshikiryo I, Suzuki S, Nishiyama T, Watanabe M, Koyama T, Ozaki E, Watanabe I, Kuriki K, Kita Y, Ueshima H, Matsui K, Arisawa K, Uemura H, Katsuura-Kamano S, Nakamura S, Narimatsu H, Hamajima N, Tanaka H, Wakai K. Study Profile of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. J Epidemiol. 2021 Dec 5;31(12):660-668.
  • Tanaka K, Nakamura S, Narimatsu H. Nutritional Approach to Cancer Cachexia: A Proposal for Dietitians. Nutrients. 2022; 14(2):345.


External Links

Hiroto Narimatsu


Sho Nakamura